In combination w/ statins for mixed dyslipidemia in patients w/ CHD or CHD risk equiv who are receiving optimal statin therapy; decrease elevated serum total cholesterol & LDL, triglyceride, & Apo B conc & increase HDL conc in the management of primary hypercholestrolemia & mixed dyslipidemia; severe hypertrigylceridemia.
Dosage/Direction for Use
Hypercholesterolemia or mixed hyperlipidemia 135 mg once daily. Hypertriglyceridemia 45-135 mg once daily.
Administration
May be taken with or without food: Swallow whole, do not open/chew/crush/dissolve.
Contraindications
Hypersensitivity to fenofibrates or fenofibric acid. Known photoallergy or phototoxic reaction during treatment w/ fibrates or ketoprofen. Active liver disease including primary biliary cirrhosis & unexplained, persistent liver function abnormality. Pre-existing gallbladder disease. Chronic or acute pancreatitis with the exception of acute pancreatitis due to severe hypertriglyceridemia. Severe renal impairment or ESRD including those receiving dialysis. Lactation.
Special Precautions
May significantly elevate hepatic transaminases. Patients w/ mild to moderate renal impairment. Discontinue in patients who develop markedly elevated creatine phosphokinase conc or if myopathy/myositis is suspected or diagnosed. Severe hypertriglyceridemia. Pancreatitis.
May increase risk of myopathy including rhabdomyolysis w/ colchicine & statins. May enhance effect of anticoagulants. May increase conc of ezetimibe. May increase risk of hypoglycemia w/ insulin, glimepiride. Increased risk of renal function deterioration w/ cyclosporine.
Sign Out
